Membrane bending by protein crowding is affected by protein lateral confinement
نویسندگان
چکیده
منابع مشابه
Membrane fission by protein crowding.
Membrane fission, which facilitates compartmentalization of biological processes into discrete, membrane-bound volumes, is essential for cellular life. Proteins with specific structural features including constricting rings, helical scaffolds, and hydrophobic membrane insertions are thought to be the primary drivers of fission. In contrast, here we report a mechanism of fission that is independ...
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Layer-by-Layer (LbL) is a method which can be used for nanoscale coating and surface functionalization of a material. LbL technique mainly uses the electrostatic attracting between charged materials (polyelectrolytes, nanoparticles, etc.) and an oppositely charged surface. In this study, protein separation (BSA) from lactose solution was carried out using the LbL self-assembly method, which was...
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PURPOSE Retinoschisin (RS) is a retina-specific, secreted protein implicated in X-linked juvenile retinoschisis and essential for the structural and functional integrity of the retina. This biochemical characterization and ultrastructural localization of RS in intact murine retina was performed to further understanding of the molecular basis of its function. METHODS Subcellular fractions and ...
متن کاملStatistical thermodynamics of membrane bending-mediated protein-protein attractions.
Highly wedge-shaped integral membrane proteins, or membrane-adsorbed proteins can induce long-ranged deformations. The strain in the surrounding bilayer creates relatively long-ranged forces that contribute to interactions with nearby proteins. In contrast, to direct short-ranged interactions such as van der Waal's, hydrophobic, or electrostatic interactions, both local membrane Gaussian curvat...
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Integral membrane proteins deform the surrounding bilayer creating long-ranged forces that influence distant proteins. These forces can be attractive or repulsive, depending on the proteins’ shape, height, contact angle with the bilayer, as well as the local membrane curvature. Although interaction energies are not pairwise additive, for sufficiently low protein density, thermodynamic propertie...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2016
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2016.03.009